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Next-generation sequencing discovery of circulating miRNA changes compared with baseline (V1) after 6 months (V3) and 24 months (V6) of denosumab therapy in postmenopausal women. Volcano plots depict the log2 transformed fold-change and log10 transformed P values. A, Visit 3 vs Visit 1; B, Visit 6 vs Visit 1. The total number of miRNAs included in the statistical analysis after filtering is indicated below each plot.
