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. 2022 Nov 19;108(5):1154–1165. doi: 10.1210/clinem/dgac667

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© The Author(s) 2022. Published by Oxford University Press on behalf of the Endocrine Society.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 3. — Reverse transcription quantitative polymerase chain reaction (RT-qPCR) confirmation of miRNA serum levels in 21 subjects and 5 time points. Line plots for the 7 miRs that were confirmed to change over time are shown as the median percentage of change in miRNA levels together with the interquartile range (n = 18). Data for patients with a decrease in spine BMD after 2 years (n = 3) is highlighted in gray. One-way ANOVA with RM using the normalized Cq-values: *adjusted P values between 0.01 and 0.05, **adjusted P values between 0.01 and 0.001, ***adjusted P values between 0.001 and 0.0001.