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Current model of Megakaryocyte and platelet subpopulations. Intravascular lung megakaryocytes with pro-platelet protrusions produce platelets that enter the bloodstream along with bone marrow-derived platelets. Extravascular megakaryocytes have a smaller, more sessile morphology and their function has not been characterized. No direct comparisons of BM and lung derived platelets have been performed and there are no available biomarkers specific for lung platelets.
