Table 3. Pharmacokinetic Parameters for Pure NAR and DES-NAR^a,^b,^c.

pharmacokinetic parameters	NAR (pure)	DES-NAR
AUC 0–t (ng/mL*h)	226.367 ± 4.2**	466.325 ± 7.2**
Cmax (ng/mL)	31.24 ± 2.3**	53.41 ± 4.1**
Tmax (h)	4.1 ± 0.6*	3.2 ± 0.8*
t1/2 (h)	3.43 ± 1.1*	4.12 ± 1.5*
MRT (h)	6.46 ±1.7**	8.28 ± 2.2**
relative bioavailability (%)		206.00

^aMean ± SD (n = 6), Significant difference at p < 0.05, **Significant difference at p < 0.01.

^bAUC_0–t—Area under curve until last observation, C_max—Peak of maximum concentration.

^cT_max—Time of peak concentration, t_1/2—Elimination half-life, MRT—Mean residence time.