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Domain organization of primary sequences of histidyl-tRNA synthetase (HARS) and efzofitimod. A schematic view of the domain organization of HARS (A) and efzofitimod (B). The ribbon structure of efzofitimod depicting the active moiety (HARS aa2-60) is shown in (C). Abbreviations: AA = amino acid; Fc = fragment crystallizable; HARS = histidyl-tRNA synthetase; IgG1 = immunoglobulin 1 (1).
