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(A) Schematic of key immune cells that form sarcoidosis granulomas. (B) NRP2 mRNA expression measure by in situ hybridization (ISH). (C) NRP2 in both skin and lung tissue samples from sarcoidosis patients is highly expressed throughout granulomas but not in the surrounding tissue. Lung tissue from a sarcoidosis patient was co-stained for NRP2 and the CD68 macrophage marker. Granulomas in this sample were composed primarily of CD68+ macrophages that express NRP2 (11).
