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[1,2]‐Brook rearrangement/strain‐release‐driven anion relay reaction. a) Scope of silyl enol ether functionalization. b) Application to the synthesis of PF‐04418948. Reactions performed with 0.20 mmol of crude 4 a, see Supporting Information for full conditions. Isolated yields from 4 a given. a 1H NMR yield. b One‐pot reaction from 7 a. c Reaction warmed to rt for 16 h. d Basic aqueous workup. e Acidic aqueous workup. f With TBAF and Cs2CO3. g With BF3⋅OEt2. h With TsN=IPh or CAN.
