TABLE 1.

Number of cases and prevalence of cases with vascular disruption anomalies (excluding genetic conditions) according to registry for birth years 2005–2017

Registry	First year	Last year	Vascular disruption cases	Total births (10,000 s)	Prevalence per 10,000 births (95% CI)	Percentage of all births to mothers <20 years old (%)
Denmark, Odense	2005	2015	63	5.5	11.5 (8.9–14.7)	1.6
UK, Wales	2005	2017	475	44.6	10.7 (9.7–11.7)	6.9
UK, PHE/Northern England	2005	2017	432	42.5	10.2 (9.2–11.2)	7.6
Germany, Saxony Anhalt	2005	2017	216	22.5	9.6 (8.3–10.9)	4.9
UK, PHE/Wessex	2005	2017	353	38.8	9.1 (8.2–10.1)	4.8
UK, PHE/EMSY	2005	2017	631	73.1	8.6 (8.0–9.3)	6.7
UK, PHE/SW England	2005	2017	544	64.2	8.5 (7.8–9.2)	4.9
France, Auvergne	2005	2017	146	17.4	8.4 (7.1–9.9)	2.5
France, Paris	2005	2017	232	34	6.8 (6.0–7.8)	0.8
The Netherlands, North	2005	2017	148	22	6.7 (5.7–7.9)	1.5
Switzerland, Vaud	2005	2017	66	10.5	6.3 (4.9–8.0)	0.7
UK, PHE/Thames Valley	2005	2017	236	38.8	6.1 (5.3–6.9)	3.3
Spain, Basque	2005	2016	145	24.2	6.0 (5.1–7.0)	1.3
France, Brittany	2011	2017	144	24.5	5.9 (5.0–6.9)	1.1
Croatia, Zagreb	2005	2017	46	8.3	5.5 (4.0–7.4)	3.8
Ireland, Cork & Kerry	2005	2017	68	12.5	5.4 (4.2–6.9)	2.0
Poland, Wielkopolska	2005	2017	258	49.9	5.2 (4.6–5.8)	4.0
Belgium, Antwerp	2005	2016	126	24.5	5.1 (4.3–6.1)	1.8
Italy, Emilia Romagna	2005	2017	248	50.5	4.9 (4.3–5.6)	1.3
Austria, Styria	2005	2016	61	12.6	4.8 (3.7–6.2)	2.9
Italy, Tuscany	2005	2017	178	37.9	4.7 (4.0–5.4)	1.2
Ireland, SE Ireland	2005	2016	41	8.8	4.7 (3.4–6.3)	3.2
Ireland, Dublin	2005	2012	95	21	4.5 (3.7–5.5)	3.3
Malta, Malta	2005	2016	20	5	4.0 (2.4–6.2)	5.1
Spain, Valencian Region	2007	2017	175	53	3.3 (2.8–3.8)	2.4
Portugal, South Portugal	2005	2017	73	24.1	3.0 (2.4–3.8)	4.5
Total			5,220	770.7

Abbreviations: EMSY, East Midlands and South Yorkshire; PHE, Public Health England; SW, South West.