TABLE 2.
Type of anomaly according to whether the case was born in the United Kingdom or in other European countries
| In Europe (excl. UK) | In the United Kingdom | Prevalence in Europe (excl. UK) versus in the United Kingdom a | ||||||
|---|---|---|---|---|---|---|---|---|
| Number of cases | % | Prevalence per 10,000 births a | Risk reduction per 5 years increase in maternal age a | Number of cases | % | Prevalence per 10,000 births a | ||
| Transverse limb reduction defects | 1,004 | 39 | 2.14 | 0.94 (0.89–1.00) | 653 | 24 | 2.16 | p = .921 |
| Gastroschisis | 730 | 29 | 1.56 | 0.46 (0.43–0.49) | 1,345 | 50 | 4.45 | p < .001 |
| Small intestinal atresia | 401 | 16 | 0.86 | 1.05 (0.96–1.15) | 258 | 10 | 0.85 | p = .681 |
| Congenital constriction bands | 196 | 8 | 0.42 | 0.86 (0.76–0.98) | 251 | 9 | 0.83 | p = .054 |
| Poland's anomaly | 81 | 3 | 0.17 | 0.95 (0.78–1.16) | 29 | 1 | 0.10 | p = .090 |
| Limb–body‐wall complex | 58 | 2 | 0.12 | 0.89 (0.70–1.13) | 103 | 4 | 0.34 | p = .085 |
| Hydranencephaly | 38 | 1 | 0.08 | 0.86 (0.65–1.14) | 20 | 1 | 0.07 | p = .486 |
| Moebius syndrome | 31 | 1 | 0.07 | 1.10 (0.79–1.52) | 7 | 0 | 0.02 | p = .024 |
| Transverse limb reduction defect with gastroschisis or intestinal atresia | 10 | 0 | 0.02 | b | 5 | 0 | 0.02 | p = 1.00 |
| Total | 2,549 | 100 | 5.44 | 0.77 (0.74–0.80) | 2,671 | 100 | 8.85 | p < .013 |
a
Adjusted for registry and maternal age.
b
Model not fitted due to lack of data.