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. 2022 Nov 24;132(2):197–210. doi: 10.1111/bcpt.13813

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© 2022 The Authors. Basic & Clinical Pharmacology & Toxicology published by John Wiley & Sons Ltd on behalf of Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society).

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Michaelis–Menten plots of CYP2D‐mediated dextromethorphan O‐demethylation (A), CYP2E1‐mediated chlorzoxazone hydroxylation (B) and CYP3A‐mediated midazolam 1′‐ (C) and 4‐ (D) hydroxylation in rat liver microsomes. Animals were treated with ip injections of 200‐mg/kg TAA (n = 7) or saline (n = 7) three times a week for 10 weeks, followed by a 10‐day washout period. The symbols and error bars represent the mean and SE values, respectively, and the lines represent the nonlinear regression fit of the experimental data.