Table 3.
SR‐BI SNP genotypes and allele frequencies
| HCV RNA |
HCVIshak fibrosis |
HCVIshak fibrosis |
|||
|---|---|---|---|---|---|
| SRB1 genotype | Positive | Negative | Severe | Mild | |
| n = 267 | n = 107 | n = 92 | n = 160 | ||
| rs4238001 | GG | 211 (79.0) | 85 (79.4) | 70 (76.1) | 130 (81.3) |
| GA | 52 (19.5) | 20 (18.7) | 22 (23.9) | 27 (16.9) | |
| AA | 4 (1.5) | 2 (1.9) | 0 (0.0) | 3 (1.9) | |
| rs61932577 | CC | 217 (81.3) | 80 (74.8) | 74 (80.4) | 129 (80.6) |
| CT | 48 (18.0) | 27 (25.2) | 17 (18.5) | 30 (18.8) | |
| TT | 2 (0.7) | 0 (0.0) | 1 (1.1) | 1 (0.6) | |
| rs5888 | CC | 70 (26.2) | 37 (34.6) | 19 (20.7) | 48 (30.0)a , b |
| CT | 137 (51.3) | 53 (49.5) | 45 (48.9) | 84 (52.9) | |
| TT | 60 (22.5) | 17 (15.9) | 28 (30.4) | 28 (17.5) | |
| SRB1 alleles | N = 534 | N = 214 | N = 184 | N = 320 | |
|---|---|---|---|---|---|
| rs4238001 | G | 474 (88.8) | 190 (88.8) | 162 (88.0) | 287 (89.7) |
| A | 60 (11.2) | 24 (11.2) | 22 (12.0) | 33 (10.3) | |
| rs61932577 | C | 482 (90.3) | 187 (87.4) | 165 (89.7) | 288 (90.0) |
| T | 52 (9.7) | 27 (12.6) | 19 (10.3) | 32 (10.0) | |
| rs5888 | C | 277 (51.9) | 127 (59.4) | 83 (45.1) | 180 (56.3)c |
| T | 257 (48.1) | 87 (40.6) | 101 (54.9) | 140 (43.7) | |
Abbreviations: n, number of subjects; N, number of alleles; percentages are given in brackets.
a
Genotype versus disease severity p = 0.039 (χ 2 test);
b
Homozygous genotype versus disease severity p = 0.014 (χ 2 test);
c
Allele frequency versus disease severity p = 0.016 (χ 2 test).