Table 1.

The surface biomolecules of EV involved in intercellular communications

Category	Sub-category	Example	Roles	Ref
Protein	Tetraspanin	CD9	EV uptake	[82]
		CD63	EV uptake	[82]
		CD81	EV uptake	[82]
		CD82	EV uptake	[82]
	Lectin	transmembrane C-type lectins	EV uptake	[63]
		transmembrane Siglecs	EV uptake	[63]
		cytosolic galectins	EV uptake	[63]
	Integrin	α6β4, α6β1	EV uptake	[83]
		αvβ5	EV uptake	[83]
	Scaffold protein	ALIX	EV biogenesis	[84]
		Syntenin	EV biogenesis	[85]
	Antigen-presenting protein	MHC class I	Immune response	[86]
		MHC class II	Immune response	[86]
Lipid	Glycerophospholipids	phosphatidylserine	EV signaling and uptake	[87]
	Sphingolipids	Ceramide	EV signaling	[88]
	Cholesterol	Cholesterol	EV secretion	[89]
Glycan	Proteoglycan	HSPG	EV uptake	[90, 91]