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(a) In P450cam Thr252 is believed to accept a hydrogen bond from Cpd 0, which encourages protonation on the distal oxygen to generate Cpd I. [1b] (b) Asp251 is hypothesized to rotate in and out of the active site, delivering protons into the active site.[ 1b , 18 ] The potential in and out positions of the D251 residue have been shown here with the rotation into the active site to facilitate proton delivery highlighted by the arrow.
