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Enantioselectivity of sulfoxidation of 4‐ethylthiobenzoic acid by WT CYP199A4 and the T252E, D251N and T252A mutants.
|
|
CYP199A4 isoform |
|||
|---|---|---|---|---|
|
ee of 4‐ethylsulfinylBA product (%) |
T252E |
WT |
T252A |
D251N |
|
NADH/O2‐driven reaction[a] |
68 % |
83 % |
82 % |
38 % |
[a] The enantioselectivity of the NADH/O2‐driven reaction. BA: benzoic acid.
