Table 3.
CPET results before and after Trikafta
| Before | After | p Value | |
|---|---|---|---|
| Peak VO2 (ml/min) | 1864.4 ± 603.0 | 1861.4 ± 501.2 | 1 |
| Peak VO2 (ml/min/kg) | 32.6 ± 9.0 | 32.4 ± 7.1 | 0.87 |
| Peak VO2%pred | 76.7 ± 19.9 | 78.4 ± 16.3 | 0.79 |
| Ventilatory threshold | 38.6 ± 9.3 | 41.3 ± 13.0 | 0.35 |
| Peak VO2/HR | 10.17 ± 3.68 | 10.49 ± 2.95 | 0.49 |
| Peak VO2/HR% | 85.00 ± 21.48 | 86.14 ± 18.85 | 0.87 |
| Peak VE/VO2 | 44.6 ± 12.25 | 40.7 ± 6.27 | 0.61 |
| VE/VCO2 at VT | 38.3 ± 7.28 | 33.7 ± 5.04 | 0.018 |
| VE/VCO2 slope | 32.97 ± 11.65 | 28.84 ± 3.32 | 0.49 |
| BR (L/min) | 24.69 ± 20.32 | 36.64 ± 28.46 | 0.091 |
| BR% | 21.71 ± 11.01 | 28.57 ± 14.28 | 0.089 |
| Low BR | 2 (28.6%) | 2 (28.6%) | 1.00 |
Note: n = 7, three on a cycle ergometer and four on a treadmill. Values are presented as mean ± SD.
Abbreviations: BR, breathing reserve; CPET, cardio‐pulmonary exercise testing; HR, heart rate; ml, milliliters; min, minute; kg, kilograms; L, liters; SD, standard deviation; VCO2, carbon dioxide output; VE, minute ventilation; VO2, oxygen uptake; VT, Ventilatory threshold.