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. 2023 Apr 12;25:59. doi: 10.1186/s13075-023-03042-6

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Simplified schematic of the Wnt signalling pathway. Wnt signalling occurs through canonical and non-canonical pathways. Two of the major non-canonical pathways are Wnt/CaMKII and Wnt/PCP. Members of the Wnt ligand family can bind to a multitude of different receptors. Different Wnt ligand/receptor combinations lead to differences in the relative amount of canonical and non-canonical pathway activation. The figure was created using Biorender.com