Table 1.
Antiviral and antiproliferative activities of the thiamyxins. Half maximal inhibitory concentrations against three RNA viruses (IC50) values determined simultaneously to half maximal cytotoxic concentrations (CC50) in infected cells.
|
Test organism |
|
IC50 and corresponding CC50 [μM] |
|||
|---|---|---|---|---|---|
|
|
Thiamyxin A |
Thiamyxin B |
Thiamyxin C |
Thiamyxin D |
|
|
hCov‐229E‐luc [a] |
IC50 |
2.47 |
2.39 |
>10 |
>10 |
|
Huh‐7.5 Fluc infected |
CC50 |
>10 |
>10 |
>10 |
>10 |
|
DENV‐R2A [b] |
IC50 |
nd |
0.56 |
14.56 |
nd |
|
Huh‐7 infected with DENV‐R2A |
CC50 |
nd |
2.25 |
>50 |
nd |
|
ZIKV‐H/PF/2013 [c] |
IC50 |
nd |
1.07 |
>15 |
nd |
|
Huh‐7 infected with ZIKV‐H/PF/2013 |
CC50 |
nd |
2.25 |
>50 |
nd |
[a] positive control remdesivir IC50=5.6 nM. [25] [b] positive control ribavirin IC50=2.3 μM. [c] positive control ribavirin IC50=2.5 μM nd=not determined.