TABLE 2.
Biological markers, circulating biomarkers of endothelium activity, and extracellular microvesicles in SCD patients with and without vasculopathy
| Total SCD patients | SCD patients with no vasculopathy | SCD patients with vasculopathy | p‐value | |
|---|---|---|---|---|
| Hb (g/dl) | 9,7 ± 1.4 | 9,47 ± 1.3 | 10,19 ± 1.6 | .437 |
| HbF (%) | 9.3 ± 5.8 | 10.17 ± 6.5 | 7.8 ± 3.8 | .364 |
| WBC (×109/L) | 8,91 ± 2.5 | 8,50 ± 2.4 | 9,85 ± 2.5 | .314 |
| Platelet count (109/L) | 356 ± 189 | 363 ± 193 | 342 ± 174 | .801 |
| LDH (IU/L) | 342 ± 119 | 325 ± 124 | 377 ± 104 | .684 |
| Creatinine (μmol/L) | 64,5 ± 15 | 64,1 ± 13.8 | 65,7 ± 17.9 | .175 |
| CEC (cel/μl) | 2.5 [0.5–7] | 2 [0.5–5.5] | 6 [1–10.5] | .390 |
| EPC (cel/μl) | 0.13 [0.07–0.24] | 0.165 [0.07–0.27] | 0.1 [0.02–0.15] | .230 |
| E‐selectin (ng/ml) | 41 [32–56] | 33 [25–48] | 49 [38–67] | .015 * |
| Ery‐EVs (events/μl) | 2815 [1007–4750] | 2969 [1018–4750] | 2767 [970–5589] | .887 |
| PEVs (events/μl) | 6532 [4693–11 183] | 7374 [5025–13 127] | 5768 [3431–8061] | .365 |
| EEV (events/μl) | 118 [57–156] | 122 [68–158] | 86 [56–167] | .116 |
| LEV (events/μl) | 40 [17–126] | 68 [22–242] | 25 [12–47] | .937 |
Note: Data expressed as median [25th–75th percentile] or as mean ± SD of the two samples mean of each patient. Bold values indicate the statistically significant with p‐value < 0.05 (p < .05).
Abbreviations: Ery‐EV, erythrocyte‐derived extracellular microvesicles; EEV, endothelial‐derived extracellular microvesicles; Hb, hemoglobin; HbF, fetal hemoglobin, LDH: lactate dehydrogenase; LEV, leucocytes‐derived extracellular microvesicles; PEV, platelet‐derived extracellular microvesicles.
*
Statistically significant p‐value (p < .05).