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. 2022 Nov 10;71(3):571–587. doi: 10.1002/glia.24295

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© 2022 The Authors. GLIA published by Wiley Periodicals LLC.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Transcriptomic analysis of astrocytes purified from the striatum and the midbrain of αSyn overexpressing mice. Animals were sacrificed at 2 weeks after AAV9 administration in the SNpc. The striatum and the midbrain were dissected out and a cell suspension was prepared from these regions. Astrocytes were separated based on ACSA2 expression for RNA sequencing. (a) Venn diagram showing overlap of differentially expressed genes (p < .01) between ACSA2⁺ cells from control and αSyn mice of the two regions(n = 3 animals/group). (b) Graphical summary of the pathways, upstream regulators and biological functions predicted to be altered in ACSA2⁺ cells from the midbrain of αSyn mice. (c) GSEA plot of the LPS reactive astrocyte signature enriched in midbrain astrocytes of αSyn mice.