TABLE 1.

MIC values of common clinical antibiotics and FFA when used to treat COL-R Gram-negative bacteria^c

	MIC (μg/mL)
	Antibiotic at the indicated MIC breakpoints (μg/mL) (S–R)b
	ATM	CAZ	FEP	IPM	CIP	LVX	GEN	TOB	COL
Straina	8–32	8–32	8–32	2–8	0.5–2	1–4	4–16	4–16	2–4	FFA
QC
ATCC 25922	0.06	0.12	0.016	0.06	0.008	0.008	0.5	1	1
ATCC 27853	4	1	2	1	0.25	0.5	1	1	1
P. aeruginosa
TL1671	8	4	8	2	0.25	1	2	1	32	>512
TL1736	4	4	2	16	1	1	32	8	8	>512
TL1744	32	32	16	16	32	8	≥128	32	4	>512
TL2314	16	32	16	4	0.5	2	8	2	8	>512
TL2917	32	16	16	16	0.25	2	8	8	8	>512
TL2967	128	16	32	16	8	16	8	8	4	>512
TL3008	4	2	4	16	0.5	1	16	4	32	>512
TL3086	128	16	16	≥128	16	8	≥128	128	32	>512
	4–16	4–16	2–16	1–4	0.25–1	0.5–2	4–16	4–16	2–4
E. coli
DC90	≥256	32	64	≥256	64	32	≥256	128	8	>512
DC3539	64	128	≥128	0.5	64	16	128	128	8	>512
DC3599	64	16	8	1	4	8	16	8	8	>512
DC3806	64	64	16	1	4	8	16	16	8	>512
DC3846	128	64	≥256	0.5	≥256	128	≥256	64	8	>512
DC4887	1	4	32	1	4	16	16	8	8	>512
DC5286	≥256	128	≥256	0.25	128	64	4	4	8	>512
DC7333	≥256	≥256	≥256	16	≥256	128	128	≥256	4	>512
K. pneumoniae
FK169	≥128	32	32	0.25	32	16	2	2	8	>512
FK1342	≥128	≥128	≥128	0.25	1	0.5	1	4	≥128	>512
FK1913	≥128	≥128	≥128	32	≥128	128	≥128	≥128	64	>512
FK1986	0.0125	0.25	0.0125	0.25	0.0125	0.025	2	1	8	>512
FK3810	0.0125	128	≥256	32	≥256	128	≥256	≥256	64	>512
FK3994	≥256	128	≥256	32	≥256	64	≥256	≥256	64	>512
FK6556	64	64	64	16	4	8	16	16	32	>512
FK6663	≥256	≥256	≥256	32	≥256	≥256	≥256	≥256	16	>512
	—	8–32	8–32	2–8	1–4	2–8	4–16	4–16	2–4
A. baumannii
BM1539	16	8	64	16	4	2	1	1	16	>512
BM1595	2	32	8	4	64	8	128	128	4	>512
BM2349	16	64	64	16	4	8	1	1	4	>512
BM2370	8	32	128	8	128	8	4	1	8	>512
BM2412	16	64	64	16	4	8	4	1	16	>512
BM2431	64	64	64	16	4	8	1	1	32	>512
BM2622	64	64	64	8	4	8	16	16	4	>512

^aStrains in boldface type are multidrug-resistant (MDR) strains.

^bValues in boldface type indicate resistance. S–R represents the susceptible (S) breakpoint to the resistant (R) breakpoint, according to CLSI supplement M100 (34) and EUCAST (49).

^cQC, quality control; ATM, aztreonam; CAZ, ceftazidime; FEP, cefepime; IMP, imipenem; CIP, ciprofloxacin; LVX, levofloxacin; GEN, gentamicin; TOB, tobramycin, COL, colistin; FFA, flufenamic acid.