TABLE 2.

FICI values for combinations of flufenamic acid and colistin used to treat COL-R Gram-negative bacteria^a

Isolate	MIC (μg/mL)				FICI	Type of interaction
	Monotherapy		Combination therapy
	COL	FFA	COL	FFA
P. aeruginosa
TL1671	32	>512	1	32	0.094	Synergistic
TL1736	8	>512	8	>512	2	No interaction
TL1744	4	>512	4	>512	2	No interaction
TL2314	8	>512	0.5	32	0.1875	Synergistic
TL2917	8	>512	1	8	0.1406	Synergistic
TL2967	4	>512	4	>512	2	No interaction
TL3008	32	>512	1	8	0.0469	Synergistic
TL3086	32	>512	4	64	0.25	Synergistic
E. coli
DC90	8	>512	1	64	0.25	Synergistic
DC3539	8	>512	1	64	0.25	Synergistic
DC3599	8	>512	1	64	0.25	Synergistic
DC3806	8	>512	1	64	0.25	Synergistic
DC3846	8	>512	1	64	0.25	Synergistic
DC4887	8	>512	1	64	0.25	Synergistic
DC5286	8	>512	1	32	0.1875	Synergistic
DC7333	4	>512	1	64	0.375	Synergistic
K. pneumoniae
FK169	8	>512	2	16	0.2813	Synergistic
FK1342	≥128	>512	8	64	0.1875	Synergistic
FK1913	64	>512	0. 5	16	0.0391	Synergistic
FK1986	8	>512	0.125	8	0.0313	Synergistic
FK3810	64	>512	0.125	8	0.0175	Synergistic
FK3994	64	>512	2	32	0.0938	Synergistic
FK6556	32	>512	2	64	0.1875	Synergistic
FK6663	16	>512	2	64	0.25	Synergistic
A. baumannii
BM1539	16	>512	0.125	8	0.0234	Synergistic
BM1595	4	>512	0.125	8	0.0469	Synergistic
BM2349	4	>512	0.125	8	0.0469	Synergistic
BM2370	8	>512	0.125	8	0.1875	Synergistic
BM2412	16	>512	0.125	8	0.0234	Synergistic
BM2431	32	>512	0.125	8	0.0273	Synergistic
BM2622	4	>512	0.125	8	0.0469	Synergistic

^aFICI, fractional inhibitory concentration index.