TABLE 2.
Effect of the clofoctol-colistin combination on the MBC of the indicated strains
| Strain | Colistin MBC (μg/mL) at clofoctol concn (μg/mL) |
Colclofa MBC | Clofcolb MBC | MBC/MICc | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 0 | 1.14 | 2.28 | 4.56 | 9.13 | 18.25 | 36.5 | 73 | ||||
| P. aeruginosa | |||||||||||
| PAO1 | 4 | 4 | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 9.13 | 2 |
| PAO1 colr1 | 256 | 128 | 64 | 16 | 8 | 8 | 8 | 8 | 8 | 9.13 | 4 |
| BG98 | 128 | 16 | 4 | 1 | 1 | 1 | 1 | 1 | 1 | 4.56 | 1 |
| KK27 colr7 | 512 | 256 | 256 | 64 | 32 | 16 | 16 | 16 | 16 | 18.25 | 4 |
| K. pneumoniae | |||||||||||
| KP-MO-27 | 0.5 | 0.25 | 0.25 | 0.25 | 0.25 | 0.25 | 0.125 | 0.0625 | 0.0625 | 73 | 1 |
| KP-MO-5 | 128 | 32 | 8 | 8 | 4 | 4 | 4 | 4 | 4 | 9.13 | 1 |
| KP-MO-6 | 64 | 16 | 4 | 4 | 2 | 1 | 1 | 1 | 1 | 18.25 | 1 |
| KP-MO-25 | 128 | 16 | 8 | 8 | 1 | 1 | 1 | 1 | 1 | 9.13 | 1 |
| A. baumannii | |||||||||||
| ATCC 19606 | 1 | 1 | 0.5 | 0.5 | 0.5 | 0.5 | 0.25 | 0.0625 | 0.0625 | 73 | 1 |
| Ab249 | 128 | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 4.56 | 2 |
| Ab347 | 32 | 8 | 2 | 2 | 0.5 | 0.5 | 0.25 | 0.25 | 0.25 | 36.5 | 1 |
| Ab4452 | 64 | 16 | 4 | 2 | 2 | 2 | 1 | 1 | 1 | 36.5 | 2 |
a
Lowest MBC of colistin in combination with clofoctol (μg/mL).
b
Lowest MBC of clofoctol in combination with colistin (μg/mL).
c
Ratio between Colclof MBC and Colclof MIC. According to Pankey and Sabath (25), a ratio of ≤4 indicates bactericidal activity.