TABLE 1.
Voriconazole MICs of original isolates and their derived colonies of the halo (CoHs)a
| Isolatea | Voriconazole MIC (μg/mL) |
CoH classification | |||
|---|---|---|---|---|---|
| Original | Original (grown on drug) | CoH (no drug) | CoH (grown on drug) | ||
| ATCC | 1 | 2 | Susceptible | ||
| PD-9* | 0.5 | 1 | 0.5 | 1 | Persister |
| PD-104* | 1 | 2 | 1 | 2 | Persister |
| PD-254 | 2 | 2 | >8 | >8 | Resistant |
| PD-256 | >8 | >8 | >8 | >8 | Resistant |
| PD-266 | 4 | 8 | 4 | >8 | Potentially heteroresistant |
a
Voriconazole MICs of the original isolates and their derived CoH, grown in the absence or presence of low (0.12 μg/mL) concentrations of voriconazole, as indicated. Susceptibility or resistance was determined based on the MIC calculated from Broth dilution assays, using the breakpoints defined by Guinea (152). *, Persistence.