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. 2023 Jan 30;11(2):e03441-22. doi: 10.1128/spectrum.03441-22

TABLE 2.

Probability of target attainment (PTA) for 3 dosage regimens with intermittent and prolonged infusion (2 h and 4 h) for a range of MICs

MIC (mg/L) PTA (%)a
Intermittent infusion, 20 min
Prolonged infusion
2 h
4 h
1 g × 3 1 g × 4 1.2 g × 4 1 g × 3 1 g × 4 1.2 g × 4 1 g × 3 1 g × 4 1.2 g × 4
0.125 99.94 100 100 100 100 100 100 100 100
0.25 99.66 100 100 100 100 100 100 100 100
0.5 98.01 99.98 99.98 100 100 100 100 100 100
1 90.39 99.75 99.82 99.97 100 100 100 100 100
2 63.99 96.55 97.14 98.97 100 100 100 100 100
4 17.93 72.38 77.09 80.72 99.92 99.94 99.88 100 100
8 0.46 14.37 22.29 12.9 75.27 80.82 64.98 88.26 97.25
16 0 0.13 0.57 0.05 4.75 11.49 2.2 9.81 25.61
a

Values in boldface indicate PTAs of >90%.