TABLE 2.
Probability of target attainment (PTA) for 3 dosage regimens with intermittent and prolonged infusion (2 h and 4 h) for a range of MICs
| MIC (mg/L) | PTA (%)a |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| Intermittent infusion, 20 min |
Prolonged infusion |
||||||||
| 2 h |
4 h |
||||||||
| 1 g × 3 | 1 g × 4 | 1.2 g × 4 | 1 g × 3 | 1 g × 4 | 1.2 g × 4 | 1 g × 3 | 1 g × 4 | 1.2 g × 4 | |
| 0.125 | 99.94 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 |
| 0.25 | 99.66 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 |
| 0.5 | 98.01 | 99.98 | 99.98 | 100 | 100 | 100 | 100 | 100 | 100 |
| 1 | 90.39 | 99.75 | 99.82 | 99.97 | 100 | 100 | 100 | 100 | 100 |
| 2 | 63.99 | 96.55 | 97.14 | 98.97 | 100 | 100 | 100 | 100 | 100 |
| 4 | 17.93 | 72.38 | 77.09 | 80.72 | 99.92 | 99.94 | 99.88 | 100 | 100 |
| 8 | 0.46 | 14.37 | 22.29 | 12.9 | 75.27 | 80.82 | 64.98 | 88.26 | 97.25 |
| 16 | 0 | 0.13 | 0.57 | 0.05 | 4.75 | 11.49 | 2.2 | 9.81 | 25.61 |
Values in boldface indicate PTAs of >90%.