TABLE 1.
MIC values of all CREC strains for three carbapenems and other antibiotics, their STs, the genotypes of carbapenemases, the Inc type of carbapenem-carrying plasmid, and other β-lactamase genesa
| Patient ID | Isolated strain | MLST | Carbapenemase | Inc type of carbapenem-carrying plasmid | Other β-lactamase(s) | MIC (mg/L) |
|||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| MEM | IPM | ETP | COL | TGC | CZA | ||||||
| 1 | DY71 | ST101 | KPC-2 | IncFII | CTX-M-14, TEM-1, EC-18 | 1 | 2 | 4 | 0.5 | 0.25 | 0.5 |
| 2 | DY76 | ST131 | CTX-M-27, EC-5 | 4 | 2 | 32 | 1 | 0.125 | 0.5 | ||
| 3 | DY80 | ST3337 | KPC-2 | IncN | CTX-M-3, TEM-1, EC | 1 | 4 | 4 | 1 | 0.5 | 0.25 |
| 2 | DY87 | ST131 | KPC-2 | IncN | CTX-M-27, CTX-M-3, TEM-1, EC-5 | >256 | >256 | >256 | 1 | 0.25 | 1 |
| 4 | DY88 | ST1656 | NDM-5 | IncHI2 | OXA-10, TEM-1, EC-18 | 128 | 256 | 128 | 0.5 | 0.25 | >128 |
| 4 | DY89 | ST1656 | NDM-5 | IncHI2 | OXA-10, TEM-1, EC-18 | 8 | 16 | 32 | 1 | 0.125 | >128 |
| 4 | DY94 | ST1656 | NDM-5 | IncHI2 | OXA-10, TEM-1, EC-18 | 16 | 16 | 32 | 0.5 | 0.25 | >128 |
| 4 | DY95 | ST1656 | NDM-5 | IncHI2 | OXA-10, TEM-1, EC-18 | 4 | 8 | 16 | 0.5 | 0.25 | >128 |
| 5 | DY96 | ST6913 | NDM-5 | IncFIB/IncFIC | EC | 8 | 8 | 32 | 1 | 0.25 | >128 |
| 2 | DY104 | ST131 | KPC-2 | IncN | CTX-M-27, CTX-M-3, TEM-1, EC-5 | >256 | >256 | >256 | 0.5 | 0.125 | 1 |
| 6 | DY131 | ST744 | KPC-2 | IncN | CTX-M-14, CTX-M-3, TEM-1, EC | 2 | 2 | 4 | 0.5 | 0.125 | 0.5 |
| 7 | DY143 | ST131 | CTX-M-14, CTX-M-15, OXA-1, TEM-1, EC-5 | 2 | 1 | 16 | 0.5 | 0.125 | 0.25 | ||
| 8 | DY162 | ST410 | KPC-2 | IncN | CTX-M-3, TEM-1, EC-15 | 1 | 1 | 2 | 1 | 0.125 | <0.0625 |
| 4 | DY315 | ST1656 | NDM-5 | IncHI2 | OXA-10, TEM-1, EC-18 | 8 | 4 | 4 | 0.5 | 0.25 | >128 |
| 4 | DY316 | ST1656 | NDM-5 | IncHI2 | OXA-10, TEM-1, EC-18 | 16 | 16 | 32 | 1 | 0.125 | >128 |
| 9 | DY317 | ST6913 | NDM-5 | IncFIB/IncFIC | EC | 16 | 16 | 16 | 1 | 0.5 | >128 |
a
CREC, carbapenem-resistant E. coli; ST, sequence type; ID, identifier; MLST, multilocus sequence type; MEM, meropenem; IMP, imipenem; ETP, ertapenem; COL, colistin or polymyxin E; TGC, tigecycline; CZA, ceftazidime-avibactam.