FIG 7.

In vivo models. (A) Determination of bacterial loads in the thighs of mice infected with A. baumannii isolates (n = 5 per group). The bacterial load was significantly lower in all string-positive isolates than in non-string-positive clinical isolates (P < 0.001). Each dot represents the mean for 5 mice. Student’s t test was performed (P < 0.001). (B) Kaplan-Meier survival curves for G. mellonella larvae (n = 20 per group) infected with 1 × 10⁵ CFU of each strain of A. baumannii. Curves were compared via the Mantel-Cox test with the Bonferroni correction for multiple comparisons. ATCC 19606 showed significantly increased survival compared to the string test-positive isolates. (C) Kaplan-Meier survival curves for G. mellonella larvae (n = 180 per group) infected with 1 × 10⁵ CFU of string-positive isolates of A. baumannii versus non-string-positive clinical A. baumannii isolates. The probability of survival for non-string-positive clinical isolates is lower than that for stCRAB isolates.