TABLE 1.
Genotype-phenotype associations for meropenem resistance and causes of putative OprD loss among 987 carbapenemase-negative P. aeruginosa isolates
| Genotype-phenotype association | No. of susceptible isolates (n = 465) | No. of intermediately resistant isolates (n = 97) | No. of resistant isolates (n = 425) |
|---|---|---|---|
| Intact OprD (exact match)a | 408 | 22 | 28 |
| Intact OprD (nonexact match)a | 11 | 3 | 15 |
| SNAP2 prediction: effect | 0 | 3 | 12 |
| SNAP2 prediction: neutral | 11 | 0 | 3 |
| OprD loss | 46 | 72 | 382 |
| Frameshift mutation | 13 | 33 | 177 |
| Premature stop | 17 | 22 | 111 |
| Gene truncation | 14 | 11 | 87 |
| Other indels | 0 | 2 | 3 |
| Incomplete promoterb | 2 | 3 | 2 |
| Start-loss | 0 | 0 | 2 |
| Stop-loss | 0 | 1 | 0 |
a
Intact variants with disrupted promoter regions are counted as OprD loss.
b
Counted only if oprD coding region was intact.