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. 2023 Feb 28;11(2):e02194-22. doi: 10.1128/spectrum.02194-22

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Copyright © 2023 Gardinassi et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 5 — Metabolomic signatures of recovery from acute COVID-19. (A) Two-way hierarchical clustering of significant metabolite features on a longitudinal follow-up of selected individuals with COVID-19. (B) Differential abundance of adenine and theobromine before and after recovery from COVID-19. (C) Mummichog pathway analysis of significant metabolite features. (D) Significant metabolite features before and after recovery from acute COVID-19, stratified by disease severity. (E) Mummichog pathway analysis of significant metabolite features stratified by disease severity. (F) Differential abundance of metabolite features annotated as carboxy-tocotrienol and phosphohydroxypyruvate before and after recovery from acute COVID-19, stratified by disease severity. (G) Integrative hierarchical community network underlying recovery of acute COVID-19. (H) Amplified visualization of nodes linked by purple-highlighted edges on the main network. (I) Cluster activity of cytokine cluster 1 and hematological cluster 2 between patients with mild/moderate and severe disease who recovered from acute COVID-19. ***, P < 0.001.