FIG 1.

Maximum likelihood phylogeny of 3,057 MopB domain-containing members constructed using 10,000 ultrafast bootstrap approximations. All sequences came from cultured organisms with sequenced genomes. Branches with blue circles indicate that the MopB homolog was taken from an archaeal genome. The lineages representing MopB families are named in the tree and represented by specific colors. Orange circles at a clade indicate that the lineage has lost the characteristic Mo/W-bisPGD cofactor. Magenta stars indicate that the lineage has acquired novel protein domains not found in other MopB families. Light-green triangles indicate that the MopB homologs in that family lineage no longer have a catalytic function. The light-blue square indicates that the MopB family has lost the N-terminal [4Fe-4S] iron-sulfur cluster.