TABLE 2.
Diagnostic performance of plasma mNGS testing compared to a composite reference standarda
| Plasma mNGS testing | The etiologic diagnosis of the study patients (n = 147) |
Diagnostic performance | |
|---|---|---|---|
| Infectious (n = 104) | Others (n = 43) | ||
| Positive plasma mNGS test (n = 113) | True positive (TP): 99 | False positive (FP): 14 | True positives out of mNGS Positives: 87.6%, 95% CI = 79.7 to 92.8% |
| Negative plasma mNGS tests (n = 34) | False negative (FN): 5 | True negative (TN): 29 | True negatives out of mNGS negatives: 85.3%, 95% CI = 68.2 to 94.5% |
| Diagnostic performance | Positive percent agreement: 95.2%, 95% CI = 88.6 to 98.2% | Negative percent agreement: 85.3%, 95% CI = 68.2 to 94.5% | |
a
The composite reference standard combined the results from all microbiological tests from cultures, serology and PCR performed within seven days of presentation and clinical adjudication made by treating team.