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Conservation and diversity in RdRp motif C. (A) Sequence logo, produced with WebLogo (Crooks et al. 2004), showing overall amino acid frequencies in the core amino acid triplet and the five flanking amino acids on either side. All nonidentical trimmed RdRp sequences in our study were used (cdhit -c 1.0). (B) Schematic representation of motif C central triplet variability overlaid on the inferred evolutionary relationships of RNA viruses from Wolf et al. (2018, 2020).
