FIG 4.

Transmitted resistance to each antituberculosis drug. The light-blue and dark-blue bars indicate the number of strains with acquired and transmitted resistance, respectively, to the drugs shown on the bottom of the figure. If the genetically clustered strains share the same resistance-conferring mutation, they are regarded as a clone resistant to the corresponding drug. The number of clones with transmitted resistance are shown in dark-green bars, while single mutants, considered acquired resistance, are shown in light green. The average sizes of transmission clusters with resistance to each indicated drug are shown in the lower subfigure.