Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Effective population sizes of the six largest drug-resistant clusters. Blue and red dashed lines indicate the estimated acquisition dates of mutations conferring resistance to isoniazid and rifampicin, respectively. Multiple lines indicate the acquisition of mutations on different branches or second mutations conferring resistance to the same drug. Subfigures a to f corresponded to clusters L20_01, L20_08, L20_13, L20_15, L23_04, and L23_13.
