TABLE 1.
The genetic characteristics of all Tibetan clinical M. tuberculosis strains and the large drug-resistant clusters included in the study
| Characteristica | Total no. (%) of samples (N = 576) | No. (%) of strains in the largest clusters (N = 372) |
|---|---|---|
| Lineage | ||
| Lineage 2 | 524 (91.0) | 372 (100) |
| Lineage 3 | 16 (2.8) | 0 (0) |
| Lineage 4 | 36 (6.2) | 0 (0) |
| Drug-resistance profile | ||
| Drug sensitive | 230 (39.9) | 131 (35.2) |
| Drug resistant | 115 (20.0) | 65 (17.5) |
| MDR-TB | 183 (31.8) | 143 (38.4) |
| Pre-XDR-TB/XDR-TB | 48 (8.3) | 33 (8.9) |
| Genetic clustering | ||
| 5-SNP cluster | 281 (48.8) | 199 (53.5) |
| 12-SNP cluster | 381 (66.1) | 268 (72.0) |
| 30-SNP cluster | 480 (83.3) | 337 (90.6) |
| 50-SNP cluster | 518 (89.9) | 363 (97.6) |
| No. of 50-SNP clusters | 50 | 11 |
| Avg 50-SNP cluster size | 10.7 | 33.8 |
a
MDR-TB, multidrug-resistant tuberculosis; XDR-TB, extremely drug-resistant tuberculosis; SNP, single-nucleotide polymorphism.