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. 2023 Mar 9;11(2):e03633-22. doi: 10.1128/spectrum.03633-22

FIG 5.

FIG 5

Multipanel box plot comparisons of intra- and intersubject metagenome dissimilarities based on 400 randomly selected pairwise Bray-Curtis distance combinations across ecological niches in the CF airway habitat. (A) In general, with respect to the metagenome composition, the longitudinal samples (intrasubject) were more similar to each other than cross-sectional intersubject samples (Wilcoxon test, P < 0.001, r = 0.13, CI = 0.06 to 0.2). (B) While the metagenome compositions of interpatient and intrapatient nasal lavage samples (top) were found to be similar (NAS, Wilcoxon test, P > 0.05), interpatient sputum samples (SPU; Wilcoxon test, P < 0.0001, r = 0.44, CI = 0.33 to 0.55) and throat swabs (THR; Wilcoxon test, P < 0.01, r = 0.47, CI = 0.15 to 0.7) were significantly more dissimilar than longitudinal samples from the same patient (bottom). This personalized signature was also detected when assessing the dissimilarity between inter- and intrapatient metagenomes of sputum samples and throat swabs (Wilcoxon test, P < 0.05, r = 0.26, CI = 0.06 to 0.43).