Table 3.
Pharmacokinetic estimates for the final population pharmacokinetic model.
| Estimate | RSE% | |
|---|---|---|
| V (L) | 0.81 | 6.6% |
| IIV V | 24% | 26% |
| Cl (L/hr) | 0.09 | 11% |
| IIV Cl | 28% | 11% |
| Hill coefficient for clearance | 4.42 | 19% |
| TMA50 (weeks) | 26.3 | 7% |
| Exponent of Scr on Cl | 0.48 | 19% |
| Residual variability b | 0.3 | 9.9% |
V, volume of distribution; IIV, interindividual variability; Cl, total body clearance; TMA, is the PMA at which CL is 50% of the mature value; Scr, serum creatinine; b, proportional error; RSE, relative standard error.