Table 2.
Meta-analyses on susceptibility considering different genotypes
| ACE1_rs4646994_rs1799752Gene | N studies | Cases | Controls | OR (95% CI) | p | I2 | ||
|---|---|---|---|---|---|---|---|---|
| Events | Total | Events | Total | |||||
| ACE1_rs4646994_rs1799752 | ||||||||
| DD | 10 | 750 | 20,664 | 1405 | 4827 | 1.41 (0.97–2.05) | 0.07 | 87% |
| DI | 10 | 917 | 2398 | 0.8 (0.51–1.26) | 0.34 | 92% | ||
| II | 10 | 399 | 1034 | 0.69 (0.48–1) | 0.05 | 80% | ||
| ACE2_rs2285666 | ||||||||
| GG | 4 | 368 | 679 | 409 | 935 | 1.27 (0.58–2.82) | 0.55 | 90% |
| AG | 4 | 96 | 149 | 0.77 (0.46–1.29) | 0.33 | 64% | ||
| AA | 4 | 44 | 54 | 1.12 (0.26–4.82) | 0.88 | 84% | ||
| IFTM3_rs12252 | ||||||||
| CC | 3 | 9 | 1034 | 0 | 875 | 5.67 (1.01–31.77) | 0.05 | 0% |
| CT | 3 | 101 | 55 | 1.64 (1.15–2.33) | 0.007 | 0% | ||
| TT | 3 | 924 | 820 | 0.56 (0.39–0.79) | 0.001 | 0% | ||
| TMPRSS2_rs12329760 | ||||||||
| CC | 4 | 1165 | 2033 | 3094 | 4824 | 0.87 (0.68–1.11) | 0.27 | 72% |
| CT | 4 | 718 | 1456 | 1.10 (0.94–1.3) | 0.24 | 37% | ||
| TT | 4 | 150 | 254 | 1.01 (0.54–1.91) | 0.97 | 84% | ||
| TNFα_rs1800629 | ||||||||
| AA | 4 | 543 | 1617 | 170 | 890 | 1.11 (0.51–2.40) | 0.79 | 89% |
| GA | 4 | 601 | 366 | 1.22 (0.74–2.01) | 0.44 | 85% | ||
| GG | 4 | 473 | 360 | 0.63 (0.29–1.38) | 0.25 | 94% | ||