Table 3.

Meta-analyses on severity considering different genotypes

Gene	N studies	Severe disease		Not severe disease		OR (95% CI)	p	I2
		Events	Total	Events	Total
ACE1_rs4646994_rs1799752
DD	15	422	1223	565	1977	1.61 (1.21–2.14)	0.001	60%
DI	13	484	1155	815	1855	0.87 (0.68–1.11)	0.27	50%
II	15	273	1223	511	1977	0.67 (0.49–0.93)	0.02	55%
ACE2_rs2285666
GG	4	290	480	284	454	1.47 (0.77–2.80)	0.24	62%
AG	4	64		105		0.51 (0.35–0.74)	0.0005	0%
AA	4	126		65		0.89 (0.31–2.54)	0.83	61%
IFTM3_rs12252
CC	4	16	332	21	782	2.26 (1.05–4.89)	0.04	0%
CT	4	41		97		1.00 (0.67–1.49)	0.98	39%
TT	4	275		664		0.82 (0.55–1.21)	0.32	0%
TMPRSS2_rs12329760
CC	4	145	384	367	749	0.92 (0.45–1.91)	0.83	83%
CT	4	172		302		1.04 (0.68–1.59)	0.86	54%
TT	4	67		80		0.93 (0.46–1.87)	0.84	41%
TNFα_rs1800629
AA	5	420	896	125	752	1.91 (0.44–8.32)	0.39	94%
GA	5	316		292		0.87 (0.58–1.3)	0.50	61%
GG	5	160		335		0.36 (0.07–1.75)	0.20	95%

Meta-analyses with p < 0.005 are in bold