Table 4.
Meta-analyses on severity considering different genetic models
| Gene | N studies | N participants | OR (95% CI) | p | I2 |
|---|---|---|---|---|---|
| ACE1_rs4646994_rs1799752 | |||||
| Dominant (DD vs II + DI) | 13 | 3042 | 1.50 (1.10–2.06) | 0.01 | 67% |
| Recessive (DD + ID vs II) | 13 | 3105 | 1.31 (0.94–1.81) | 0.11 | 59% |
| Homozygous (DD vs II) | 13 | 1720 | 1.53 (1.23–1.9) | 0.0002 | 63% |
| Additive () | 13 | 2275 | 1.41 (1.02–1.94) | 0.04 | 62% |
| ACE2_rs2285666 | |||||
| Dominant (GG + GA vs AA) | 3 | 454 | 2.24 (0.90- 5.61) | 0.08 | 0% |
| Recessive (GG vs GA + AA) | 3 | 454 | 2.18 (1.28- 3.72) | 0.04 | 16% |
| Homozygous (GG vs AA) | 3 | 370 | 2.52 (1.00—6.33) | 0.05 | 0% |
| Additive (GG vs GA) | 3 | 418 | 2.03 (1.10- 3.76) | 0.02 | 0% |
| IFTM3_rs12252 | |||||
| Dominant (CC + CT vs TT) | 3 | 630 | 1.14 (0.68- 1.94) | 0.61 | 0% |
| Recessive (CC vs CT + TT) | 3 | 630 | 2.27 (0.98- 5.25) | 0.05 | 0% |
| Homozygous (CC vs TT) | 3 | 539 | 1.60 (0.58- 4.42) | 0.37 | 0% |
| Additive (CC vs CT) | 3 | 124 | 2.60 (1.04- 6.52) | 0.04 | 0% |
| TMPRSS2_rs12329760 | |||||
| Dominant (CC + CT vs TTI) | 4 | 2492 | 0.72 (0.04- 12.18) | 0.82 | 96% |
| Recessive (CC vs CT + TT) | 4 | 1132 | 0.92 (0.44- 1.89) | 0.82 | 83% |
| Homozygous (CC vs TT) | 4 | 659 | 1.08 (0.33- 3.47) | 0.90 | 73% |
| Additive (CC vs CT) | 4 | 986 | 0.89 (0.44- 1.80) | 0.74 | 80% |
| TNFα_rs1800629 | |||||
| Dominant (AA + AG vs GG) | 4 | 748 | 1.17 (0.85–1.60) | 0.34 | 38% |
| Recessive (AA vs AG + GG) | 4 | 440 | 1.26 (0.82–1.92) | 0.29 | 0% |
| Homozygous (AA vs GG) | 4 | 428 | 1.14 (0.96–1.36) | 0.14 | 0% |
| Additive (AA vs GA) | 4 | 445 | 1.13 (0.72–1.77) | 0.61 | 0% |