Table 5.
Meta-analyses on mortality considering different genotypes
| Gene | N studies | Died | Survivors | OR (95% CI) | P | I2 | ||
|---|---|---|---|---|---|---|---|---|
| Events | Total | Events | Total | |||||
| ACE1_rs4646994_rs1799752 | ||||||||
| DD | 3 | 27 | 98 | 180 | 406 | 0.42 (0.25–0.69) | 0.0006 | 51% |
| DI | 3 | 43 | 141 | 1.44 (0.90–2.30) | 0.13 | 0% | ||
| II | 3 | 28 | 85 | 2.00 (1.17–3.42) | 0.01 | 34% | ||
| ACE2_rs2285666 | ||||||||
| GG | 1 | 41 | 46 | 189 | 251 | 2.69 (1.02–7.11) | 0.05 | n.a |
| AG | 1 | 4 | 36 | 0.57 (0.19–1.68) | 0.31 | n.a | ||
| AA | 1 | 1 | 26 | 0.19 (0.03–1.45) | 0.11 | n.a | ||
| IFTM3_rs12252 | ||||||||
| CC | 3 | 3 | 121 | 31 | 991 | 2.52 (0.59–10.84) | 0.21 | 0% |
| CT | 3 | 27 | 183 | 1.58 (0.99–2.54) | 0.06 | 0% | ||
| TT | 3 | 88 | 762 | 0.58 (0.37–0.91) | 0.02 | 0% | ||
| TMPRSS2_rs12329760 | ||||||||
| CC | 2 | 3 | 30 | 74 | 290 | 0.30 (0.08–1.07) | 0.06 | 0% |
| CT | 2 | 19 | 128 | 2.29 (1.02–5.16) | 0.04 | 25% | ||
| TT | 2 | 7 | 79 | 0.81 (0.34–1.96) | 0.65 | 37% | ||
| TNFα_rs1800629 | ||||||||
| AA | 3 | 70 | 112 | 533 | 1380 | 2.4 (0.08–70.13) | 0.61 | 93% |
| GA | 3 | 25 | 539 | 0.39 (0.06–2.43) | 0.31 | 87% | ||
| GG | 3 | 10 | 308 | 0.35 (0.05–2.75) | 0.32 | 81% | ||
n.a. not applicable