Table 2.
Association of testican-2 and incident ESKD and CKD progression in AASK, CRIC, and ARIC
| ESKD | CKD Progression | |||
|---|---|---|---|---|
| HR (95% CI) | P Value | HR (95% CI) | P Value | |
| AASK | ||||
| Model 1 | 0.54 (0.47 to 0.63) | 1.3 × 10−17 | 0.63 (0.55 to 0.71) | 5.2 × 10−14 |
| Model 2 | 0.76 (0.65 to 0.89) | 4.6 × 10−4 | 0.80 (0.70 to 0.92) | 0.0012 |
| Model 3 | 0.84 (0.72 to 0.98) | 0.023 | 0.88 (0.77 to 1.01) | 0.064 |
| CRIC | ||||
| Model 1 | 0.56 (0.53 to 0.59) | 4.9 × 10−99 | 0.60 (0.57 to 0.63) | 3.1 × 10−92 |
| Model 2 | 0.89 (0.84 to 0.95) | 8.0 × 10−4 | 0.88 (0.83 to 0.93) | 1.4 × 10−5 |
| Model 3 | 0.95 (0.89 to 1.02) | 0.14 | 0.94 (0.88 to 1.00) | 0.048 |
| ARIC | ||||
| Model 1 | 0.23 (0.17 to 0.30) | 8.8 × 10−23 | 0.45 (0.36 to 0.56) | 1.5 × 10−12 |
| Model 2 | 0.58 (0.38 to 0.89) | 0.012 | 0.76 (0.58 to 1.00) | 0.051 |
| Model 3 | 0.54 (0.36 to 0.83) | 0.0044 | 0.75 (0.57 to 0.98) | 0.038 |
HRs are per SD. Covariates: model 1. AASK: adjusted for age and sex; CRIC/ARIC: adjusted for age, sex, and race. Model 2: AASK: model 1+mGFR, heart disease, smoking, systolic BP, and BMI; CRIC/ARIC: model 1+eGFR, heart disease, diabetes, smoking, systolic BP, anti–hypertensive medications, and BMI. Model 3. AASK/CRIC: model 2+Log (PCR); ARIC: model 2+Log (ACR). HR, hazard ratio; CI, confidence interval; AASK, American Study of Kidney Disease and Hypertension; CRIC, Chronic Renal Insufficiency Cohort; ARIC, Atherosclerosis Risk in Communities; BMI, body mass index; PCR, urine protein-to-creatinine ratio; ACR, urine albumin-to-creatinine ratio.