Table 5.
Solute plasma levels favoring furosemide clearance compared with iGFR (above 90th percentile regression line)
| −log(P): Furosemide | −log(P): iGFR | Compound | Protein Binding (%) | CoV | CLr-to-CrCl Ratio |
|---|---|---|---|---|---|
| 8.8 | 6.9 | 2-[(4-Aminobenzoyl)amino]acetic acid | 19 | 0.3 | 10.9 |
| 7.3 | 5 | 1,4-Cyclohexanedicarboxylic acid | 15 | 0.3 | 2.4 |
| 6.6 | 5.8 | Biotin | 2 | 0.3 | 2.7 |
| 6.4 | 5 | 3′-Sialyllactose | 21 | 0.3 | 5.7 |
| 5.5 | 3.5 | Phenylacetylglycine | 18 | 0.3 | 4.3 |
| 5.5 | 2.7 | Choline | 6 | 0.2 | 0.2 |
| 5.4 | 3.8 | 3-Dehydrocarnitine | 11 | 0.1 | 11.3 |
| 5.1 | 4.6 | 2′-O-Methylinosine | 4 | 0.5 | 0.6 |
| 4.6 | 4 | 3-Hydroxyanthranilic acid | 15 | 0.3 | 3.2 |
| 4.6 | 3.2 | 2-[(4-Aminobenzoyl)amino]acetic acid | 8 | 0.5 | 21.3 |
| 4.2 | 3.3 | N-Isovalerylglycine | 24 | 0.5 | 10.2 |
| 4.1 | 3.3 | Picolinuric acid | 37 | 0.8 | 47.6 |
| 4 | 3.4 | α-Galactosamine-1-phosphate | 17 | 0.2 | 3.1 |
| 4 | 2.5 | Hexanoyl-L-carnitine | 30 | 0.4 | 1.9 |
| 4 | 3 | Pantothenic acid | 24 | 0.6 | 0.5 |
| 3.9 | 2.9 | Glu-Val | 15 | 0.3 | 1 |
| 3.9 | 3.1 | Isomaltose A | 18 | 0.9 | 3.3 |
| 3.9 | 2.2 | N-Acetylmannosamine | 12 | 0.3 | 0.9 |
| 3.7 | 2.7 | 4-Hydroxyhippuric acid | 25 | 0.3 | 3.6 |
| 3.5 | 1.6 | N-Acetylneuraminic acid | 4 | 0.4 | 2.4 |
Candidate solutes are ordered by the kidney clearance association with furosemide clearance. iGFR, iohexol GFR; CoV, coefficient of variation; CLr-to-CrCl ratio, solute clearance-to-creatinine clearance ratio.