Fig 3. Variation in benzimidazole (BZ) EC₁₀ dose-response and slope estimates can be explained by genetic variation across strains.

(A) Strain-specific EC₁₀ estimates (e) for each benzimidazole are displayed for each strain. Standard errors for each strain- and anthelmintic-specific EC₁₀ estimates are shown. (B) Strain-specific slope estimates (b) for each benzimidazole are displayed for each strain. Standard errors for each strain- and anthelmintic-specific slope estimate are indicated by the line extending vertically from each point. (C) The broad-sense (x-axis) and narrow-sense heritability (y-axis) of normalized animal length measurements were calculated for each concentration of each benzimidazole (Methods; Broad-sense and narrow-sense heritability calculations). The color of each cross corresponds to the log-transformed dose for which those calculations were performed. The horizontal line of the cross corresponds to the confidence interval of the broad-sense heritability estimate obtained by bootstrapping, and the vertical line of the cross corresponds to the standard error of the narrow-sense heritability estimate.