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. 2023 Apr 14;14:2124. doi: 10.1038/s41467-023-37773-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Representative H&E images of lungs of hamsters infected with 10⁴ TCID₅₀ of either the wild-type (WT) SARS-CoV-2 virus (USA-WA1/2020) or the 3CLpro (L50F-E166A-L167F) nirmatrelvir resistant (3CLpro^res) virus at day 4 post-infection (pi) showing peribronchial inflammation (blue arrows), peri-vascular inflammation with vasculitis (red arrows), and foci of bronchopneumonia (green arrows). Scale bars, 200 μm. b Cumulative severity score from H&E stained slides of lungs from hamsters infected with the WT virus or the (3CLpro^res) virus at day 4 pi. Individual data and median values are presented and the dotted line represents the median score of untreated non-infected hamsters. Data were analyzed with the two-sided Mann−Whitney U-test, ns = non-significant (p = 0.5). Data presented are from 2-independent studies with a total n = 12 per group.