Fig. 4. MPM driver genes in the MESOMICS cohort.
Top, tumor mutational burden (TMB), number of segments or copy number burden (CNB) and structural variant burden (SVB) of each sample. Main, oncoplot describing genomic alterations in IntOGen and structural variant MPM driver genes per sample. These genomic events can co-occur with copy number changes. Large indels and translocations refer to structural variant events detected by structural variant callers while fusion transcripts are detected at the transcriptomic level. Each gene is also annotated as belonging to one focal or arm-level GISTIC event, as well as for being regulated by DNA methylation (right bars). Right, frequency of alterations within the cohort. For each gene, the dark green dot represents the frequency of structural variants. In the legend, ERG indicates whether the sample has one or more alteration in an ERG. Key clinical, epidemiological, morphological and technical features are given for each sample. PCAWG, Pan-Cancer Analysis of Whole Genomes; SNV, single-nucleotide variant; SV, structural variant.