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. 2023 Mar 6;42(16):1294–1307. doi: 10.1038/s41388-023-02632-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — A L2HG and D2HG levels in tumors derived from control (shLacZ, n = 23), L2HGDH-knockdown (shL2HGDH #1, n = 12; shL2HGDH #2, n = 20) HT29 cells. B Rate of growth following subcutaneous implantation of shLacZ (n = 23), shL2HGDH #1 (n = 12), and shL2HGDH #2 (n = 21) HT29 cells. Data represent the mean ± SEM. **P < 0.01 and ***P < 0.001. C mRNA expression of L2HGDH, ATF4, and ATF4 target genes in tumors derived from shLacZ (n = 23), shL2HGDH #1 (n = 12), and shL2HGDH #2 (n = 19) HT29 cells. D Volcano plot showing the levels of amino acids that were significantly altered in in tumors derived from shLacZ (n = 16) and shL2HGDH #2 (n = 14) HT29 cells. Red dots indicate significantly upregulated amino acids. Levels of amino acids were detected using capillary electrophoresis time-of-flight mass spectrometry.