The basal medium exclusive protein (A) serotransferrin (TF) and (B) serum albumin (ALB) were significantly increased post 2 day exposures with PG/VG+CBD oil+VEA. After the 3rd exposure, (C) serotransferrin (TF) and (D) serum albumin (ALB) showed further increased levels after PG/VG+CBD oil+VEA in addition to significant increases after PG/VG+CBD oil. Total precursor intensities in each panel are the sums of precursor peptide ion intensities for a given protein, used to assess the presented protein abundances. The mean and SEM values are indicated by major and minor horizontal bars, respectively. Statistical significance was determined by Friedman’s nonparametric test and Dunn’s multiple comparison analysis. The p-value is indicated by * ≤ 0.05, *** ≤ 0.005, **** ≤ 0.001.