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. Author manuscript; available in PMC: 2024 May 1.
Published in final edited form as: J Appl Toxicol. 2022 Nov 30;43(5):680–693. doi: 10.1002/jat.4415

Figure 7: PG/VG, CBD oil and VEA aerosol exposure causes leakage of cytosolic proteins and cytotoxicity markers GAPDH and LDH from HBE cells.

Figure 7:

The typical cytosolic proteins (A) glyceraldehyde-3-phosphate dehydrogenase (GAPDH) serotransferrin and (B) lactate dehydrogenase (LDH) were significantly increased after the 3 day exposure to PG/VG and PG/VG+N. PG/VG+CBD oil- and PG/VG+CBD oil+VEA-exposed cultures displayed the highest apical surface liquid levels after the 2nd exposure, indicating an earlier toxicity impact. Total precursor intensities in each panel are the sums of precursor peptide ion intensities for a given protein, used to assess the presented protein abundances. Mean and SEM values are indicated by major and minor horizontal bars, respectively. Statistical significance was determined by Friedman’s nonparametric test and Dunn’s multiple comparison analysis, and the p-value is indicated by * ≤ 0.05, ** ≤ 0.01, *** ≤ 0.005, **** ≤ 0.001.