The relative proteomic quantification of major secreted proteins in the HBE lining fluid. (A) BPI fold containing family B member 1 (BPIFB1), (B) mucin 4 (MUC4), (C) galectin 3 binding protein (LG3BP) and (D) secretory leukocyte peptidase inhibitor (SLPI) showed significant reductions after CBD oil or VEA containing aerosol exposure. Total precursor intensities in each panel are the sums of precursor peptide ion intensities for a given protein, used to assess the presented protein abundances. The mean and SEM values are indicated by major and minor horizontal bars, respectively. Statistical significance was determined by Friedman’s nonparametric test and Dunn’s multiple comparison analysis, and the p-value is indicated by ** ≤ 0.01, *** ≤ 0.005.