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. Author manuscript; available in PMC: 2024 Apr 1.
Published in final edited form as: Alzheimers Dement. 2023 Jan 13;19(4):1579–1586. doi: 10.1002/alz.12905

Figure 1. Hypothesized conceptual framework of mobility in the clinical disease stage of dementia, modified from Jack et al. 20107.

Figure 1.

The added curves of mobility impairment are hypothesized to occur either before or after brain structural changes. The occurrence of mobility impairment at different stages may indicate different types of pathologies. (Obtaining permission from the publisher Elsev